fig7

Figure 7. Typical application examples of drug delivery and in vivo analyte detection. (A) Demonstration of the feasibility of laser-triggered photothermal unsealing of PTMF chambers in three different environments: air (a), deionized water (b), and 1% agarose gel (b), with laser beams transmitted through optical fibers^[45]. Copyright 2020, Elsevier; (B) Functionalization processes in silicon dioxide and hydrogel fibers (a and b) and glucose-boron complexation in the hydrogel matrix inducing positive volumetric shift (c)^[168]. Copyright 2019, Elsevier; (C) Schematic diagram of the ARC/Ag/MOF sensor structure^[175]. Copyright 2023, Elsevier; (D) Polymerization of the sensing gel at the tip of the optical fiber during the manufacturing process of the OF sensor (a) and integration of AuNPs into PBA-based hydrogel OF sensor (b)^[176]. Copyright 2024, Wiley; (E) Experimental setup for detection of hemoglobin not drawn to scale (a-e)^[177]. Copyright 2023, Elsevier; (F) Schematic illustration of npRDW TFs for neurotransmitters’ SERS signal detection (a) and optical images (b) and SEM images of the npRDW TF (c)^[46]. Copyright 2023, Wiley. PTMF: Polymer 3D microstructured film; ARC: ab initio REPEAT charge; MOF: metal-organic framework; OF: optical fiber; AuNPs: Au nanoparticles; PBA: phenylboronic acid; npRDW: nonplanar repeated dewetting; TFs: tapered fibers; SERS: surface-enhanced Raman spectroscopy; SEM: scanning electron microscope.