fig3

From: Nanomedicine-enabled ultrasound immunotherapy: from immunogenic cell death to systemic immune activation

Figure 3. Two main phenotypes of tumor-associated neutrophils within the tumor microenvironment. Reproduced with permission^[84]. Copyright 2025, Signal Transduction and Targeted Therapy. TME: Tumor microenvironment; PMN-MDSC: polymorphonuclear myeloid-derived suppressor cell; NDN: normal-density neutrophil; LDN: low-density neutrophil; GMP: granulocyte-macrophage progenitor; IL-8: interleukin-8; TGF: transforming growth factor; IFN: interferon; CXCL: CXC-chemokine ligand; TAN: tumor-associated neutrophil; APC: antigen-presenting cell; GM-CSF: granulocyte-macrophage colony-stimulating factor; ICAM-1: intercellular cell adhesion molecule-1; CD95: cluster of differentiation 95; MHCII: major histocompatibility complex class II; CCL: chemokine (C-C motif) ligand; G-CSF: granulocyte colony-stimulating factor.