fig1

From: Nanomedicine-enabled ultrasound immunotherapy: from immunogenic cell death to systemic immune activation

Figure 1. Schematic illustration of nanomedicine-enabled ultrasound immunotherapy for systemic antitumor immune activation. CRT: Calreticulin; DC: dendritic cell; CD8⁺: cluster of differentiation 8 (positive); CD4⁺: cluster of differentiation 4 (positive); STING: stimulator of interferon genes; PD-1: programmed death receptor-1; PD-L1: programmed cell death ligand 1; TAN: tumor-associated neutrophil; TME: tumor microenvironment; MDSC: myeloid-derived suppressor cell.