fig5

Figure 5. Potential activation of the gut-brain axis by Lachnospiraceae treatments. (A-D) Correlations between butyrate and BAs levels (DCA, LCA, UDCA, and TUDCA) (E); Heatmap of correlations between microbiota-derived metabolites with neurological factors; (F-K) Correlation of TNF-α with cerebral factors (Tph2, Slc6a4, Gad1, Gabbr1, GFAP, and Slc1a2). Note: (A-D, F-K) Spearman correlation analysis; r and P values are indicated in each panel. (E) Spearman correlation analysis with Benjamini-Hochberg FDR correction; *adjusted q < 0.05, **adjusted q < 0.01; all displayed correlations also meet |r| > 0.6. TMAO: trimethylamine N-oxide; GABA: γ-aminobutyric acid; KYN: kynurenine; Trp: tryptophan; 5-HT: serotonin; DCA: deoxycholic acid; LCA: lithocholic acid; UDCA: ursodeoxycholic acid; TUDCA: tauroursodeoxycholic acid; GFAP: glial fibrillary acidic protein; TNF-α: Tumor necrosis factor-α; BA: bile acids; FDR: false discovery rate.