fig1

Figure 1. Model of systemic vasoconstriction by Kv1.5 KO. (A) KCNA5 expression in the LV was downregulated in male KO mice and female KO mice. (B) Aortic diameter was smaller in KO male and female mice. (C) Aortic artery acceleration time (AAT) was faster in KO male and female mice. (D) KCNA5 expression in the RV was downregulated in male KO mice and female KO mice. (E) Pulmonary artery (PA) diameter was smaller in male and female KO mice. (F) Pulmonary artery acceleration time (PAT) was lower in KO male and female mice. Data are expressed as mean ± SEM. *P < 0.05 within sex t-test by Student’s t-test. Blue: male (M), red: female (F).