fig2

Figure 2. Schematic diagram illustrating how mRNA 3’UTR shortening represses its ceRNA partner in trans by releasing the common miRNA(s). 3’UTR shortening of mRNA-X allows its escape from miRNA-mediated repression, therefore increasing mRNA-X expression. However, the release of the common miRNA(s) from binding to the long 3’UTR of mRNA-X will result in the repression of the ceRNA partner mRNA-Y. 3’UTR: 3’ untranslated region; ceRNA: completing endogenous RNA; miRNA: microRNA.