fig8

Figure 8. P-gp-overexpressing cells transport selected photosensitizers (BPD, Rose Bengal, and Redaporfin*). Flow cytometry was performed to assess the intracellular fluorescence of photosensitizer. The raw mean fluorescence intensity values are reported for individual histograms. BPD, redaporfin, and rose bengal show higher uptake in the presence of P-gp inhibitor valspodar. Heterogeneity in the single-cell population for the redaporfin-only group was observed in MCF-7 TX400 cells. NT: Not treated, control; PS: photosensitizer only; PS+Inhibitor: photosensitizer + valspodar; BPD: benzoporphyrin derivative.