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Figure 2. Contents and functions of CAF-derived EVs. (A) CAF-derived EVs regulate tumor proliferation; (B) CAF-derived EVs regulate tumor invasion and metastasis; (C) CAF-derived EVs regulate the tumor immune microenvironment; (D) CAF-derived EVs regulate tumor angiogenesis/lymphangiogenesis. CAF: Cancer-associated fibroblasts; EVs: extracellular vesicles; DC: dendritic cell; Mac: macrophage; Fb: fibroblast; Endo: endotheliocyte; TME: tumor microenvironment; IL-6: interleukin-6; CDEs: CAF-derived EVs.