fig4

Figure 4. Epithelial to mesenchymal transition (EMT). Genes defining EMT (gene set M5930) (A); genes down-regulated in DLD1 cells (colon carcinoma) over-expressing LEF1 (gene set: M2903) (B); representative images (24 h) of a scratch wound migration (0 mg/mL Matrigel) and invasion (6 mg/mL Matrigel) assay of the nutlin-3 resistant A549.R2 cell line and parental A549 cell line (C); real-time migration (D) and invasion (E). RWD: relative wound density presented as mean +/- SD of 3 biological replicates