Special Issue

Topic: Akkermansia muciniphila and Its Health Benefits: From Associations to Causality

A Special Issue of Microbiome Research Reports

ISSN 2771-5965 (Online)

Submission deadline: 31 Dec 2024

Guest Editor(s)

Dr. Anneleen Segers
Laboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands.
Dr. Willem M. de Vos
Laboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands.

Special Issue Introduction

Akkermansia muciniphila, a mucin-degrading symbiotic bacterium, has emerged as a significant contributor to gut health since its isolation from the human intestine in 2004. Extensive research has been conducted on this bacterium ever since. In healthy individuals, the colonic abundance of A. muciniphila ranges between 1%-4% and its abundance is inversely correlated with several diseases, such as inflammatory bowel diseases, obesity and type 2 diabetes. While high-fiber diets and polyphenol-rich foods have been found to increase A. muciniphila levels in the colon, there is limited understanding of the mechanistic aspects underlying this stimulation by dietary components.

By maintaining a healthy gut barrier, A. muciniphila controls immune responses and limits inflammation, a root cause of many diseases. Both live and pasteurized A. muciniphila administration can reinforce the intestinal barrier and counteract metabolic disturbances in both animals and humans. Importantly, pasteurized A. muciniphila is safe for human consumption, enabling its commercial use in weight gain management. In the understanding of A. muciniphila's mode of action, the pilus-associated signaling protein (PAS, Amuc_1100) has been identified as a pivotal component. PAS mediates many of A. muciniphila's health-promoting effects by activating Toll-like receptor 2 and enhancing barrier function. In addition, other secreted and outer membrane proteins such as P9, as well as metabolites such as short-chain fatty acids and cell envelope fragments, have been shown to have health-promoting effects.

This Special Issue aims to showcase publications that expand on the current knowledge about A. muciniphila to provide further mechanistic insights into its mode of action and identify causal relationships between A. muciniphila and its health-promoting effects. We welcome manuscripts presenting original research, reviews, perspectives, opinions and commentaries on all aspects of A. muciniphila and its health benefits, including but not limited to:
● Therapeutic potential and mode of action of PAS, extracellular vesicles or other extracellular components of A. muciniphila;
A. muciniphila-host interaction mechanisms in health and disease;
● Mechanistic insights into the effect of dietary components on A. muciniphila's abundance and/or activity;
● Insights into the interaction between A. muciniphila and other members of the gut microbiota;
● Novel Akkermansia species and their therapeutic potential.

Submission Deadline

31 Dec 2024

Submission Information

For Author Instructions, please refer to https://www.oaepublish.com/mrr/author_instructions
For Online Submission, please login at https://oaemesas.com/login?JournalId=mrr&SpecialIssueId=MRR230625
Submission Deadline: 31 Dec 2024

Contacts: Fiona Yin, Managing Editor, editorialoffice@mrrjournal.net

                Louise Xu, Assistant Editor,  Louise@microbiomeresearchreports.net


Published Articles

Possible application of Akkermansia muciniphila in stress management
Open Access Review 9 Sep 2024
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The biofunction of Akkermansia muciniphila in intestinal-related diseases
Open Access Review 4 Sep 2024
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Akkermansia beyond muciniphila - emergence of new species Akkermansia massiliensis sp. nov.
Open Access Perspective 24 Jun 2024
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Omics-based analysis of Akkermansia muciniphila cultivation in food-grade media
Open Access Original Article 16 Jun 2024
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Pangenomic analysis identifies correlations between Akkermansia species and subspecies and human health outcomes
Open Access Original Article 10 Jun 2024
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Microbiome Research Reports
ISSN 2771-5965 (Online)

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