fig1

Figure 1. Conceptual framework of L-MAFLD. The central illustration depicts visceral adiposity and hepatic steatosis, emphasizing that L-MAFLD is a systemic multisystem disease associated with insulin resistance, cardiometabolic complications, CKD, GI neoplasia, increased mortality, sarcopenia, and gut dysbiosis, despite a lean body habitus. CKD: Chronic kidney disease; GI: gastrointestinal; L-MAFLD: lean metabolic dysfunction-associated fatty liver disease; MAFLD: metabolic dysfunction-associated fatty liver disease; T2DM: type 2 diabetes mellitus.