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Figure 1. Lipid flux as a key player in liver regeneration. Schematic illustration of the Janus-faced actions of lipid fluxes on liver regeneration. Phase-locked transient steatosis may eventually facilitate liver regeneration by providing energy, substrates and signals. Conversely, prolonged lipid overload will impair liver regeneration by promoting endoplasmic reticulum stress, mitochondrial dysfunction and inflammation. This original illustration was created using Servier Medical ART (SMART) and is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). ER: endoplasmic reticulum; CPT1A: Carnitine Palmitoyltransferase 1A; TRAS: transient regenerative-associated steatosis.