fig5

Figure 5. Change in lipidomic signatures and differences in lipid classes in obese individuals with IGT relative to the control group. (A) Pie charts depicting the proportion of significantly differential lipids in the IGT group versus the NC group; (B) Hierarchical clustering heatmap showing the 208 lipids in which a significant difference existed between the IGT group and the NC group (adjusted VIP ＞ 1, P < 0.05, FC ≥ 2 or ≤ -0.5). Data are presented as Z-score by row, with each individual row representing 1 of the 208 significantly different lipids); (C) Comparison of up-regulated TG, DG, PC and LPC species between the IGT group and the NC group. NC: Normal control; IGT: impaired glucose tolerance; VIP: variable influence on projection; FC: fold change; Cer: ceramide; Ch: cholesterol; Che: cholesteryl ester; DG: diacylglycerol; LPC: lysophosphatidylcholine; LPE: lysophosphatidylethanolamine; PC: phosphatidylcholine; PE: phosphatidylethanolamine; TG: triacylglycerol; Hex1Cer: hexose ceramide; PEt: phosphatidylethanol; SM: sphingomyelins.