fig1

Figure 1. Main hepatic and extra-hepatic activities of estrogens. Estrogen receptor-α (Erα) and FPR2 play a crucial role in the sex-specific variations observed in the progression of MASLD, MASH, and specific extra-hepatic outcomes. The original illustration was generated using Servier Medical ART (SMART) and is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0), incorporating data from^[24,26]. FPR2: Formyl peptide receptor 2; MASLD: metabolic dysfunction-associated steatotic liver disease; MASH: metabolic dysfunction-associated steatohepatitis.