fig2
Figure 2. Overview of the design of the Mendelian randomization (MR) study. Illustration of the assumptions underpinning a MR analysis of the association between an exposure and an outcome. The arrows represent causal pathways. The dashed arrows represent potential causal associations between variables that would violate the assumptions of MR analysis. SNPs: Single nucleotide polymorphisms; LD: linkage disequilibrium.
