fig10

Figure 10. Transcriptional and miRNA regulatory networks associated with key genes. (A) Transcriptional regulatory network (red: key genes; green: transcription factors); (B) Enriched motifs and corresponding transcription factors; (C) miRNA-gene interaction network (yellow: mRNA; blue: miRNA). C2: Complement component 2; GUCY1B2: guanylate cyclase 1 soluble subunit beta 2; OLFM4: olfactomedin 4; ITPR1: inositol 1,4,5-trisphosphate receptor type 1; KLHL36: kelch like family member 36; REL: REL proto-oncogene, NF-kB subunit; MZF1: Myeloid zinc finger 1; RUNX2: RUNX family transcription factor 2; RUNX3: RUNX family transcription factor 3; HIVEP1: HIVEP zinc finger 1; NFKB1: nuclear factor kappa B subunit 1; RELA: RELA proto-oncogene, NF-kB subunit.