fig5

Figure 5. (A) Predicted median lethal dose (LD₅₀) values of 30 TDCs; (B) Distribution of HQ values for 24 TDCs. Six substances (CPPD-Q, 2-Me-BTH, NOBS, DCU, BLE, and DM) were excluded as they were not detected at any sampling site. TDCs: Tire-derived chemicals; HQ: hazard quotient; CPPD-Q: 4-N-(2-methylphenyl)-1-N-(4-mehylphenyl)benzene-1,4-diamine; 2-Me-BTH: 2-methyl-1,3-benzothiazole; NOBS: 4-(1,3-benzothiazol-2-ylsulfanyl)morpholine; DCU: 1,3-dicyclohexylurea; BLE: 9,9-dimethyl-10H-acridine; DM: 2-(1,3-benzothiazol-2-yldisulfanyl)-1,3-benzothiazole; IPPD-Q: 2-anilino-5-(propan-2-ylamino)cyclohexa-2,5-diene-1,4-dione; DTPD-Q: 1-N-phenyl-4-N-propan-2-ylbenzene-1,4-diamine; DPPD: 1-N-cyclohexyl-4-N-phenylbenzene-1,4-diamine; 6PPD: 4-N-(4-methylpentan-2-yl)-1-N-phenylbenzene-1,4-diamine; DTPD: 2-(cyclohexylamino)-5-(phenylamino)cyclohexa-2,5-diene-1,4-dione; 4-HDPA: 4-anilinophenol; BTH: 1,3-benzothiazole; CBS: N-(1,3-benzothiazol-2-ylsulfanyl)cyclohexanamine; 2-OH-BTH: 3H-1,3-benzothiazol-2-one; TMTD: dimethylcarbamothioylsulfanyl N,N-dimethylcarbamodithioate; BT: 2H-benzotriazole; 2-Me-S-BTH: 2-methylsulfanyl-1,3-benzothiazole; IPPD: 1-N,4-N-diphenylbenzene-1,4-diamine; DPG: 1,2-diphenylguanidine; 2-ABTH: 1,3-benzothiazol-2-amine; 6PPD-Q: 2,5-dianilinocyclohexa-2,5-diene-1,4-dione; DCBS: N-(1,3-benzothiazol-2-ylsulfanyl)-N-cyclohexylcyclohexanamine; RD: 2,2,4-trimethyl-1H-quinoline; DCA: N-cyclohexyl-N-methylcyclohexanamine; DCU: 1,3-dicyclohexylurea; HMMM: hexa(methoxymethyl)melamine; NOBS: 4-(1,3-benzothiazol-2-ylsulfanyl)morpholine; CPPD: 2-anilino-5-(4-methylpentan-2-ylamino)cyclohexa-2,5-diene-1,4-dione; BLE: 9,9-dimethyl-10H-acridine; DPU: 1,3-diphenylurea; DNPD: 1-N,4-N-dinaphthalen-2-ylbenzene-1,4-diamine; TBBS: N-(1,3-benzothiazol-2-ylsulfanyl)-2-methylpropan-2-amine; DM: 2-(1,3-benzothiazol-2-yldisulfanyl)-1,3-benzothiazole.