fig6

Figure 6. Linear regressions of E_β2M/C_cr on potential determinants. Scatter diagrams present data from diabetics (DM, blue) and non-diabetic controls (CTRL, orange). The graphs plot E_β2M/C_cr against (A) E_Cd/C_cr, (B) F_β2M, (C) [β₂M]_s, (D) eGFR, (E) TD_β2M/C_cr, and (F) FrTD_β2M. In (A), a positive relationship is evident in DM, and no relationship is evident in CTRL. In (B) and (C), positive relationships are evident in CTRL, and no relationships are evident in DM. Inverse relationships are evident in both groups in (D). In (E), a positive relationship is evident in CTRL, and no relationship is evident in DM. In (F), strong inverse relationships are evident in both groups. Cd: Cadmium; cr: creatinine; β₂M: β₂-microglobulin; E_β2M/C_cr: amount of β₂M excreted per volume of glomerular filtrate; DM: group with diabetes mellitus; CTRL: control group without diabetes; E_Cd/C_cr: amount of Cd excreted per volume of glomerular filtrate; F_β2M: rate of glomerular filtration of β₂M; [β₂M]_s: serum concentration of β₂M; eGFR: estimated glomerular filtration rate; TD_β2M/C_cr: amount of β₂M undergoing tubular degradation per volume of glomerular filtrate; FrTD_β2M: fractional tubular degradation of filtered β₂M.