fig5

Figure 5. Linear regressions of TD_β2M/C_cr on potential determinants. Scatter diagrams present data from diabetics (DM, blue) and non-diabetic controls (CTRL, orange). The graphs plot TD_β2M/C_cr against (A) E_Cd/C_cr, (B) F_β2M, (C) [β₂M]_s, (D) FrTD_β2M, and (E) eGFR. No relationships are evident in (A). Strong direct relationships are evident in both groups in (B) and (C). In (D), a direct relationship is evident in DM, and no relationship is evident in CTRL. In (E), a marginal inverse relationship is evident in DM, and no relationship is evident in CTRL. Cd: Cadmium; cr: creatinine; β₂M: β₂-microglobulin; TD_β2M/C_cr: amount of β₂M undergoing tubular degradation per volume of glomerular filtrate; DM: group with diabetes mellitus; CTRL: control group without diabetes; E_Cd/C_cr: amount of Cd excreted per volume of glomerular filtrate; F_β2M: rate of glomerular filtration of β₂M; [β₂M]_s: serum concentration of β₂M; FrTD_β2M: fractional tubular degradation of filtered β₂M; eGFR: estimated glomerular filtration rate.