fig2

Figure 2. Domain structure of canonical and non-canonical acetyltransferases. Acetyltransferases are classified based on their domain structural homology and substrate specificity. Canonical lysine acetyltransferases (KATs) are further grouped into three major families: the MYST family consisting of five members [KAT6A (MOZ), KAT6B (MORF), Tip60 (KAT5), KAT8 (MOF), and HBO1 (KAT7)], the GNAT family consisting of three members [HAT1, GCN5 (KAT2A), and PCAF (KAT2B)], and the p300/CBP family consisting of two members [CBP (KAT3A) and p300 (KAT3B)]. Non-canonical KATs are categorized into two primary groups: transcription coactivator-related KATs consisting of three members [TAF1 (KAT4), ELP3 (KAT9), and GTF3C4 (KAT12)] and steroid receptor coactivator-related KATs consisting of four members (NCOA1 (SRC1), NCOA3 (SRC3), NCOA2 (SRC2), and CLOCK). The number of amino acids (AA) for each human protein is listed. NEMM, N-terminal part of Enok, MOZ or MORF; PHD, PHD zinc figure; MYST, MYST-type KAT domain including zinc figure domain (blue); Acidic, acidic domain; Ser/Met-rich, serine/methionine-rich domain; Chromo, chromodomain; C2HC, C2HC-type zinc figure domain; HAT, GNAT or p300/CBP-type histone acetyltransferase domain; NRID, N-terminal nuclear receptor interaction domain; TAZ, transcription adaptor putative zinc figure domain; KIX, kinase-inducible domain (KID) interacting domain; CH2, cysteine/histidine-rich zinc figure domain; ZZ, ZZ-type zinc finger domain; NCBD, nuclear coactivator binding domain; Kinase, kinase domain; Bromo, bromodomain; SAM, S-adenosylmethionine (SAM) domain; bHLH, basic helix-loop-helix domain; PAS, Per/Arnt/Sim domain; AD, transcriptional activation domain; PAC, C-terminal to a subset of PAS motifs; Gln, glutamine-rich C-terminal domain.