fig1
From: Mechanically remodeled extracellular vesicles: drivers of disease or therapeutic opportunities?
Figure 1. Mechanical regulation of EV biogenesis and function: a mechanobiological perspective. 3D: Three-dimensional; Ca2+: calcium ion; EV: extracellular vesicle; FAK: focal adhesion kinase; MAPK: mitogen-activated protein kinase; M1: classically activated macrophages; M2: alternatively activated macrophages; Piezo1: Piezo-type mechanosensitive ion channel component 1; RhoA: Ras homolog family member A; ROCK: Rho-associated coiled-coil-containing protein kinase; TAZ: transcriptional co-activator with PDZ-binding motif; TGF-β: transforming growth factor beta; TRPV: transient receptor potential vanilloid; Wnt: wingless-related integration site; YAP: Yes-associated protein.
