fig4

Figure 4. Migrasomes expedite cancer metastasis and progression. (1) Migrasome-associated markers modulate cancer cell invasion, migration, and metastatic spread; (2) Migrasomes release signaling molecules to neighboring cells, increasing their motility and pro-metastatic behavior; (3) Migrasomes help establish an immunosuppressive TME that supports tumor progression and colonization. EGF: Epidermal growth factor; EOGT: EGF domain-specific O-linked N-acetylglucosamine transferase; GPI: glycosylphosphatidylinositol; GPI-TA: glycosylphosphatidylinositol transamidase; miRNAs: microRNAs; NDST1: N-deacetylase-N-sulfotransferase 1; PIGK: phosphatidylinositol glycan, class K; TME: tumor microenvironment.