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Figure 3. MSC-EVs attenuate histopathological damages and restore the function of the liver and kidney. (A) Histological examination of liver tissue morphology by H&E staining (scale bar = 50 μm); (B) Histological examination of kidney tissue morphology by H&E staining (top image scale bar = 50 μm, bottom image scale bar =100 μm); (C) Serum ALT level in different groups (n = 6); (D) Serum AST level in different groups (n = 6); (E) Serum Cr level in different groups (n = 6); (F) Serum BUN level in different groups (n = 6). Data were analyzed by one-way ANOVA with Tukey’s post hoc test. Data are presented as mean ± SD. ^**P < 0.01; ^***P < 0.001. MSC-EVs: Mesenchymal stem cell-derived extracellular vesicles; H&E: hematoxylin and eosin; ALT: alanine aminotransferase; AST: aspartate aminotransferase; Cr: creatinine; BUN: blood urea nitrogen; ANOVA: analysis of variance; SD: standard deviation; BDL: bile duct ligation.