fig1

Figure 1. Functional characterization of Malassezia extracellular vesicles composition and their postulated role in healthy skin and in a model of atopic dermatitis. The figure summarizes the key conclusions of the studies described in detail in the text for extracellular vesicles released by distinct Malassezia species (MalaEx), including MsEx, MfEx, and MrEx. The illustration was created in the Mind the Graph Platform, available at www.mindthegraph.com. AD: Atopic dermatitis; agr: accessory gene regulator; IL: interleukin; TNF-α: tumor necrosis factor alpha; ICAM-1: intercellular adhesion molecule-1; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; MalaEx: Malassezia-derived extracellular vesicles; MfEx: extracellular vesicles derived from M. furfur; MrEx: extracellular vesicles derived from M. restricta; MsEx: extracellular vesicles derived from M. sympodialis; PBMCs: peripheral blood mononuclear cells.