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Figure 1. Cell-type-specific ion channel and receptor mechanisms of mechanical stress-induced cardiac remodeling. Mechanical stress activates mechanosensors (Piezo1, TRP channels, NMDAR, AGTR1) and dysregulates cardiomyocyte excitation-contraction coupling channels (LTCC, Nav1.5, RyR2, NCX1), driving Ca²⁺ signaling and ROS feedback that culminate in hypertrophy, fibrosis, and electrical remodeling. The figure was created with Matplotlib (Python) and Adobe Illustrator.