fig3

From: Pathological remodeling driven by the cardiac autoantigen-dendritic cell-CD4⁺ T-cell axis under sustained mechanical stress load

Pathological remodeling driven by the cardiac autoantigen-dendritic cell-CD4<sup>+</sup> T-cell axis under sustained mechanical stress load

Figure 3. Model of effector CD4⁺ T cells, fibroblast antigen presentation, and structural remodeling in the pressure-overloaded heart. Local interactions among effector CD4⁺ T cells, cardiomyocyte injury, and fibroblast-mediated matrix remodeling in the pressure-overloaded heart. This figure summarizes the process by which, after homing to the heart, effector CD4⁺ T cells interact locally with cardiomyocytes, DCs, and fibroblasts in the presence of antigenic and inflammatory signals, accompanied by cardiomyocyte stress, fibroblast activation, collagen deposition, and ventricular remodeling. DC: Dendritic cell; CXCL9: C-X-C motif chemokine ligand 9; CXCL10: C-X-C motif chemokine ligand 10; ICAM-1: intercellular adhesion molecule 1; IL-21: interleukin-21; α-SMA: alpha-smooth muscle actin; ECM: extracellular matrix.

fig3

Portico

Portico