fig1

Figure 1. Schematic representation of the cGAS-STING pathway as a mechanistic bridge between radiotherapy and systemic antitumor immunity in HCC. cGAS: Cyclic GMP-AMP synthase; cGAMP: cyclic GMP-AMP; STING: stimulator of interferon genes; IRF3: interferon regulatory factor 3; p-IRF3: phosphorylated interferon regulatory factor 3; IFN: interferon; IFN-β: interferon beta; ISGs: interferon-stimulated genes; TCR: T-cell receptor; MHC-I: major histocompatibility complex class I; EMT: epithelial-mesenchymal transition; SOX2: SRY-box transcription factor 2; HCC: hepatocellular carcinoma.