fig3

Figure 3. Impact of amino acid metabolic reprogramming on the immune response in HCC. Sharp arrows denote positive regulation, whereas blunt arrows denote negative regulation. Upward symbols represent upregulation, whereas downward symbols represent downregulation. Major actionable targets are indicated by distinct geometric symbols: triangles represent metabolic enzymes, circles represent transporters, stars represent kinases, squares represent transcription factors, and pentagons represent immune checkpoint proteins. AHR: Aryl hydrocarbon receptor; ARG1: arginase 1; ASNS: asparagine synthetase; GCN2: general control nonderepressible 2; GLS1: glutaminase 1; IDO1: indoleamine-2,3-dioxygenase 1; PD-1: programmed cell death protein-1; SLC1A5: solute carrier family 1 member 5; STAT3: signal transducer and activator of transcription 3.