fig1

Figure 1. Schematic representation of smart nanomaterials-enabled multimodal combinatorial cancer immunotherapy. Multifunctional nanoplatforms integrating chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, metabolic regulation, and immune regulation are designed with artificial intelligence (AI)-assisted optimization to synergistically activate systemic antitumor immunity, remodel the TME, target distant metastatic sites, and optimize therapeutic intervention. Drawn by Figdraw (ID: TRWRA36009). TME: Tumor microenvironment.