Topic: Extracellular Vesicles for Wound Management

Wound healing is a highly coordinated biological process comprising four overlapping phases: hemostasis, inflammation, proliferation, and remodeling. Disruptions in these phases can lead to chronic, non-healing wounds, prolonging recovery, compromising healing quality, and potentially causing serious complications. As a safer alternative to stem cell therapy, extracellular vesicles (EVs) derived from stem cells have emerged as promising therapeutic agents for promoting wound healing and tissue regeneration. Beyond stem cell-derived EVs, recent studies have highlighted the therapeutic potential of EVs from diverse sources, including bacteria, plants, and organoids, broadening the landscape of EV-based interventions. Coupled with advances in engineering techniques and biofabrication strategies, these developments are paving the way for innovative and effective approaches for optimal wound management.

This Special Issue welcomes researchers and experts to contribute perspectives, opinions, reviews, and original research articles related - but not limited – to the following topics:

● Roles and mechanisms of EVs in wound healing and tissue regeneration;

● Strategies to enhance EV performance, including bioengineering, biofabrication, and machine learning;

● EV-based therapies, delivery systems, biomaterials, and devices for wound management (e.g., nanocarriers, microneedles, hydrogels, and organoids).