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Figure 3. EMT and histological transformation mechanisms of osimertinib-acquired resistance in EGFR-mutant NSCLC and management strategies to overcome them. Cancer cells may undergo EMT or transform into SCC or SCLC (Created with BioRender.com. https://BioRender.com/bzr4mlu). EGFR: Epidermal growth factor receptor; NSCLC: non-small-cell lung cancer; EMT: epithelial-mesenchymal transition; SCC: squamous cell carcinoma; SCLC: small cell lung cancer; lncRNA: long noncoding RNA.